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Clinical Trials of Coronavirus Drugs Are Taking Longer Than Expected

 

As the coronavirus pandemic continues to wreak havoc in the United States and treatments are needed more than ever, clinical trials for some of the most promising experimental drugs are taking longer than expected.

Researchers at a dozen clinical trial sites said that testing delays, staffing shortages, space constraints and reluctant patients were complicating their efforts to test monoclonal antibodies, man-made drugs that mimic the molecular soldiers made by the human immune system.

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The Many Symptoms of Covid-19

For a Texas nurse, the first sign that something was wrong happened while brushing her teeth — she couldn’t taste her toothpaste. For a Georgia attorney, it was hitting a wall of fatigue on a normally easy run. When a Wisconsin professor fell ill in June, he thought a bad meal had upset his stomach.

But eventually, all of these people discovered that their manifold symptoms were all signs of Covid-19. Some of the common symptoms — a dry cough, a headache — can start so mildly they are at first mistaken for allergies or a cold. In other cases, the symptoms are so unusual — strange leg pain, a rash or dizziness — that patients and even their doctors don’t think Covid-19 could be the culprit.

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Why the Coronavirus is More Likely to ‘Superspread’ Than the Flu

For a spiky sphere just 120 nanometers wide, the coronavirus can be a remarkably cosmopolitan traveler.

Spewed from the nose or mouth, it can rocket across a room and splatter onto surfaces; it can waft into poorly ventilated spaces and linger in the air for hours. At its most intrepid, the virus can spread from a single individual to dozens of others, perhaps even a hundred or more at once, proliferating through packed crowds in what is called a superspreading event.

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The Coronavirus Is New, but Your Immune System Might Still Recognize It

Eight months ago, the new coronavirus was unknown. But to some of our immune cells, the virus was already something of a familiar foe.

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As Trump Praises Plasma, Researchers Struggle to Finish Critical Studies

Since April, the Trump administration has funneled $48 million into a program with the Mayo Clinic, allowing more than 53,000 Covid-19 patients to get plasma infusions. Doctors and hospitals desperate to save the sickest patients have been eager to try a therapy that is safe and might work. Tens of thousands more people are now enrolled to get the treatment that’s been trumpeted by everyone from the president to the actor Dwayne Johnson, better known as The Rock.

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